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Selleck Chemicals
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Image Search Results
Journal: Frontiers in Microbiology
Article Title: Identification of a small molecule 0390 as a potent antimicrobial agent to combat antibiotic-resistant Escherichia coli
doi: 10.3389/fmicb.2022.1078318
Figure Lengend Snippet: Antimicrobial effects of 0390 against Escherichia coli . (A) Workflow of the in vitro high-throughput screening assay of the MINI Scaffold library, containing 5,033 MINI molecules. The OD value was determined by a microplate spectrophotometer. The structural formula and characteristics of a hit (hit compound), 0390 (6056–0390) were shown. H_acceptor: hydrogen bond acceptor count. H_donor: hydrogen bond donor count. B_rotN: rotatable bond count. LogP: oil- water partition coefficient. (B) Growth of E. coli ATCC 25922 after exposure to different concentrations of 0390 for 18 h. The experiment was repeated three times.
Article Snippet: To identify the antibacterial effects, 5,033 unique MINI Scaffold molecules, the molecules in
Techniques: In Vitro, High Throughput Screening Assay, Screening Assay, Spectrophotometry